[CANCER RESEARCH 32, 1671—1678,August 1972] SUMMARY CS7BL/6 mice were infected as neonates or as adults with Rauscher leukemia virus (RLV) and were challenged at various times thereafter with syngeneic Rauscher lymphoma
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چکیده
CS7BL/6 mice were infected as neonates or as adults with Rauscher leukemia virus (RLV) and were challenged at various times thereafter with syngeneic Rauscher lymphoma cells. In addition, sera obtained prior to challenge were tested by immunofluorescence against Rauscher lymphoma cells. Mice infected as adults with a 10' dilution of RLV exhibited strong transplantation resistance within 1 week that persisted for the entire 16-week observation period. Lower doses of RLV induced delayed transplantation resistance. Most mice also contained detectable antibody most of the time. Mice neonatally infected with RLV also developed transplantation
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Enhancement of murine sarcoma virus (Moloney) infection and tumorigenesis in vivo by coinfection with Rauscher leukemia virus.
Dual infection of mice with murine sarcoma virus (Moloney) [MSV(M)] and Rauscher leukemia virus (RLV) resulted in an enhanced MSV(M) infection, reflected by increased mortality with tumor. Significant increases in tumor incidence, induced by low concentrations of MSV(M) when inoculated into RLV-infected mice, demonstrated that RLV enhanced MSV(M) oncogenicity. Temporal studies indicated that RL...
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The recovery of spleen cells infected with Rauscher leukemia virus (RLV) and grown in Millipore diffusion chambers, the development of RLV-induced splenomegaly, and the cumulative mortality from a transplanted ascites plasma-cell tumor were all suppressed in young adult BALB/c male mice previously primed at 3-weekly intervals with x-irradiated, syngeneic embryo cells. RLV-induced splenomegaly w...
متن کاملComparative studies on the induction of transplantation resistance in BALB-c and C57BL-6 mice in three murine leukemia systems.
Syngeneic X-irradiated Friend, Moloney, and Rauscher (FAIR) lymphomas readily induce transplantation resistance in C57BL/6 mice. Similar resistance is more difficult to induce in BALB/c mice. To determine whether this difference in response is due to a lesser immunogenicity of FMR cells of BALB/c ori gin, C57BL/6 mice were pretreated with viable or X-irradiated BALB/c FMR cells, or with X-irrad...
متن کاملAbsence of plasma erythropoietin in mice with anemia induced by Rauscher leukemia virus.
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Immimofluorescence data are presented which confirm the previously reported cytotoxic antibody studies suggesting that Friend, Moloney, and Rauscher (FMR) virus-induced lymphomas possess similar surface antigens, not shared by Gross lymphomas. It is not known, however, whether the antigenic relationship demonstrable serologically is, or should necessarily be, demonstrable by transplantation stu...
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